HBV Mutation Detail Information

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Mutation Information

Mutation Site	N474H
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Amino acid_Mutation	A544C
Country	Argentina

Literature Information

PubMed PMID	25244642
Disease	Chronic hepatitis B
Published Year	2014
Journal	Journal of viral hepatitis
Title	Hepatitis B virus depicts a high degree of conservation during the immune-tolerant phase in familiarly transmitted chronic hepatitis B infection: deep-sequencing and phylogenetic analysis.
Author	Sede M,Lopez-Ledesma M,Frider B,Pozzati M,Campos RH,Flichman D,Quarleri J
Evidence	In comparison with the other 29 complete sequences of genotype D1, 13 distinctive specific point mutations were observed in the nine complete genomes from the family as follows (amino acid changes at Polymerase): A544C (N474H), T996C,A1361T (Y746F), A1634G, G2648A, T2859C (S185P),C2928T (R208C), A2991G (S229G), A3000C (I232L),G3039A (G245L),and 3171A (H289N). C3083A (S259R), G3120A (K272E),and 3171A (H289N).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation