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Mutation Information
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Mutation Site
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N462A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
Literature Information
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PubMed PMID
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31527908
|
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Published Year
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2019 |
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Journal
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PLoS pathogens |
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Title
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Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies. |
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Author
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LaBranche CC,Henderson R,Hsu A,Behrens S,Chen X,Zhou T,Wiehe K,Saunders KO,Alam SM,Bonsignori M,Borgnia MJ,Sattentau QJ,Eaton A,Greene K,Gao H,Liao HX,Williams WB,Peacock J,Tang H,Perez LG,Edwards RJ,Kepler TB,Korber BT,Kwong PD,Mascola JR,Acharya P,Haynes BF,Montefiori DC |
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Evidence
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Three mutations in V5 (N461A, N462A and T463A) had no effect but a fourth mutation in the CD4-binding loop (S365P) conferred resistance to the UCA and intermediates while not conferring resistance to mature CH103 (S4 Table).
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HIV Mutation Detail Information