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Mutation Information
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Mutation Site
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N3A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vif |
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Combined Mutation
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vif.R4A+vif.N3A |
Literature Information
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PubMed PMID
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28302150
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Published Year
|
2017 |
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Journal
|
Retrovirology |
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Title
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Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function. |
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Author
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Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK |
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Evidence
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Finally, we also observed that N3A-R4A, Q12A-V13A, M16A-R17A, N19A-T20A, and R23A-L24A mutants exhibited a significantly higher efficiency of binding to CBFbeta compared to WT Vif (Fig. 1b;values indicated in red);the potential biological significance of increased binding to CBFbeta by these mutants was not further examined in these studies.
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HIV Mutation Detail Information