Mutation Information
Mutation Site
|
N392Q |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Gp120 |
Viral Reference
|
K03455.1
|
Literature Information
PubMed PMID
|
24758333
|
Published Year
|
2014 |
Journal
|
Retrovirology |
Title
|
Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site. |
Author
|
Utachee P,Isarangkura-na-ayuthaya P,Tokunaga K,Ikuta K,Takeda N,Kameoka M |
Evidence
|
In order to generate N-linked glycosylation mutants, N186Q, N197Q, N301Q, N339Q, N386Q and/or N392Q, were introduced into proviral constructs by site-directed mutagenesis using the QuikChange site-directed mutagenesis kit (Agilent Technologies, Santa Clara, CA).
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