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Mutation Information
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Mutation Site
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N348I |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
tenofovir (TDF) |
Literature Information
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PubMed PMID
|
20010074
|
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Published Year
|
2010 |
|
Journal
|
AIDS (London, England) |
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Title
|
N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations. |
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Author
|
Sluis-Cremer N,Moore K,Radzio J,Sonza S,Tachedjian G |
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Evidence
|
However, N348I significantly decreases tenofovir susceptibility when combined with thymidine analogue mutations and etravirine susceptibility when combined with Y181C.
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HIV Mutation Detail Information