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Mutation Information
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Mutation Site
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N348I |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.N348I+rt.A360V;rt.E478Q+rt.N348I+rt.A360V |
Literature Information
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PubMed PMID
|
18547911
|
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Published Year
|
2008 |
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Journal
|
The Journal of biological chemistry |
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Title
|
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms. |
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Author
|
Ehteshami M,Beilhartz GL,Scarth BJ,Tchesnokov EP,McCormick S,Wynhoven B,Harrigan PR,Götte M |
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Evidence
|
The efficiency of rescue of DNA synthesis follows the order WT RT < TAMs < TAMs/A360V < TAMs/N348I < TAMs/A360V/N348I.
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HIV Mutation Detail Information