HIV Mutation Detail Information

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Mutation Information

Mutation Site	N332A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120
Country	US

Literature Information

PubMed PMID	32156815
Disease	HIV infection/AIDS
Published Year	2020
Journal	mBio
Title	Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.
Author	Martinez DR,Tu JJ,Kumar A,Mangold JF,Mangan RJ,Goswami R,Giorgi EE,Chen J,Mengual M,Douglas AO,Heimsath H,Saunders KO,Nicely NI,Eudailey J,Hernandez G,Morgan-Asiedu PK,Wiehe K,Haynes BF,Moody MA,LaBranche C,Montefiori DC,Gao F,Permar SR
Evidence	Yet in in utero-transmitting woman 9105, we observed a >10-fold reduction in neutralization activity against BJOX2000 N332A compared to that against the wild-type BJOX2000 virus, as well as a 12-fold reduction in neutralization activity against TRO.11 N332A compared to that against the wild-type TRO.11 virus (Fig. 3B and andC),C), suggesting the presence of bNAbs with V3 glycan specificity.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation