HIV Mutation Detail Information

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Mutation Information

Mutation Site	N302A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Genotype/Subtype	B
Immune Escape	Y

Literature Information

PubMed PMID	30538178
Published Year	2018
Journal	mBio
Title	Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation.
Author	Guzzo C,Zhang P,Liu Q,Kwon AL,Uddin F,Wells AI,Schmeisser H,Cimbro R,Huang J,Doria-Rose N,Schmidt SD,Dolan MA,Connors M,Mascola JR,Lusso P
Evidence	Identification of V3 loop residues that stabilize the Env trimer via interaction with the V2 loop tyrosines. Neutralization sensitivities of single V3 loop mutants (N300A, N302A, R304A, and K305A mutants) of HIV-1 BaL compared to those of the wild-type virus.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation