HPV Mutation Detail Information

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Mutation Information

Mutation Site	N285T
Mutation Type	Amino acid level
Gene/Protein/Region Type	L1
Genotype/Subtype	HPV16
Viral Reference	NC_001526.4
Country	India

Literature Information

PubMed PMID	31944308
Disease	Cervical intraepithelial neoplasia
Published Year	2020
Journal	Journal of medical virology
Title	Characterization of major capsid protein (L1) variants of Human papillomavirus type 16 by cervical neoplastic status in Indian women: Phylogenetic and functional analysis.
Author	Mane A,Patil L,Limaye S,Nirmalkar A,Kulkarni-Kale U
Evidence	These substitutions when mapped on 3D structure revealed that eleven and four substitutions are part of experimentally validated B- and T-cell epitopes, of which T266A and N285T were common to both types of epitopes and may impact HPV vaccine efficacy.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation