Mutation Information
Mutation Site
|
N283T |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Env |
Literature Information
PubMed PMID
|
18837996
|
Published Year
|
2008 |
Journal
|
Retrovirology |
Title
|
The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors. |
Author
|
Rossi F,Querido B,Nimmagadda M,Cocklin S,Navas-Martín S,Martín-García J |
Evidence
|
Therefore, we introduced the N283T mutation into an env clone from a brain-derived isolate and into a brain tissue-derived env clone, and the T283N change into a spleen-derived env from the same individual;however, we found that their phenotypes were not affected.
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