Mutation Information
Mutation Site
|
N279K |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Env |
Literature Information
PubMed PMID
|
31527908
|
Published Year
|
2019 |
Journal
|
PLoS pathogens |
Title
|
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies. |
Author
|
LaBranche CC,Henderson R,Hsu A,Behrens S,Chen X,Zhou T,Wiehe K,Saunders KO,Alam SM,Bonsignori M,Borgnia MJ,Sattentau QJ,Eaton A,Greene K,Gao H,Liao HX,Williams WB,Peacock J,Tang H,Perez LG,Edwards RJ,Kepler TB,Korber BT,Kwong PD,Mascola JR,Acharya P,Haynes BF,Montefiori DC |
Evidence
|
Two Env mutations were identified, one in loop D (N279K) and another in V5 (G458Y), that acted synergistically to render autologous CH505 transmitted/founder virus susceptible to neutralization by CH235 UCA.
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