HIV Mutation Detail Information

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Mutation Information

Mutation Site	N279A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120
Country	US

Literature Information

PubMed PMID	32156815
Disease	HIV infection/AIDS
Published Year	2020
Journal	mBio
Title	Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.
Author	Martinez DR,Tu JJ,Kumar A,Mangold JF,Mangan RJ,Goswami R,Giorgi EE,Chen J,Mengual M,Douglas AO,Heimsath H,Saunders KO,Nicely NI,Eudailey J,Hernandez G,Morgan-Asiedu PK,Wiehe K,Haynes BF,Moody MA,LaBranche C,Montefiori DC,Gao F,Permar SR
Evidence	To measure maternal-plasma bNAb activity, we tested viruses in the nine-virus global panel: 246F3, BJOX2000, CE1176, CNE55, TRO.11, X1632, CEO217, 25710, and CH119. To map the specificities of maternal-plasma bNAbs, we tested the following mutant viruses: BJOX2000 N160K, BJOX2000 N332A, TRO.11 N332A, TRO.11 N276Q, TRO.11 N279A, and TRO.11 G458Y.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation