Mutation Information
Mutation Site
|
N254D |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
IN |
Literature Information
PubMed PMID
|
19014951
|
Published Year
|
2009 |
Journal
|
Journal of molecular biology |
Title
|
Defining the DNA substrate binding sites on HIV-1 integrase. |
Author
|
Dolan J,Chen A,Weber IT,Harrison RW,Leis J |
Evidence
|
Of the chimeras tested, S39T K42H, Y227I, N254D, K258T R262S showed decreased or no activity with HIV-1 substrates and did not cleave the ASV substrates (data not shown).
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