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Mutation Information
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Mutation Site
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N197E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
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Viral Reference
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K03455.1
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Immune Escape
|
Y |
Literature Information
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PubMed PMID
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30709739
|
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Published Year
|
2019 |
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Journal
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Immunity |
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Title
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An Antigenic Atlas of HIV-1 Escape from Broadly Neutralizing Antibodies Distinguishes Functional and Structural Epitopes. |
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Author
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Dingens AS,Arenz D,Weight H,Overbaugh J,Bloom JD |
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Evidence
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We validated these observations using point mutants in TZM-bl neutralization assays: simply eliminating the N197 PNG via N197E resulted in ~50 fold more potent neutralization by VRC01, while N197S resulted in viral escape, increasing the IC50 by 27-fold relative to wildtype (Figure S3).
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HIV Mutation Detail Information