HIV Mutation Detail Information

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Mutation Information

Mutation Site	N185D
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120
Viral Reference	K03455.1

Literature Information

PubMed PMID	24758333
Published Year	2014
Journal	Retrovirology
Title	Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site.
Author	Utachee P,Isarangkura-na-ayuthaya P,Tokunaga K,Ikuta K,Takeda N,Kameoka M
Evidence	However, the introduction of an amino acid substitution, E185D (Figure 4A), G185D (Figure 4B) or N185D (Figure 4C), conferred b12 susceptibility to AE-Env mutants or markedly improved their b12 susceptibility.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation