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Mutation Information
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Mutation Site
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N160A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
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Country
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US |
Literature Information
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PubMed PMID
|
32156815
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Disease
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HIV infection/AIDS
|
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Published Year
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2020 |
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Journal
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mBio |
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Title
|
Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants. |
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Author
|
Martinez DR,Tu JJ,Kumar A,Mangold JF,Mangan RJ,Goswami R,Giorgi EE,Chen J,Mengual M,Douglas AO,Heimsath H,Saunders KO,Nicely NI,Eudailey J,Hernandez G,Morgan-Asiedu PK,Wiehe K,Haynes BF,Moody MA,LaBranche C,Montefiori DC,Gao F,Permar SR |
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Evidence
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Surprisingly, we did not observe plasma bNAb responses in transmitting HIV-infected woman 0601, suggesting that infant-T/F virus 0616 was selected in the absence of detectable V2 glycan-targeting bNAbs in plasma as measured by the differential neutralization activities against a panel of wild-type viruses and N160K and N160A mutant viruses that knock out PG9-like bNAb neutralizing activity (Fig. S7B).
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HIV Mutation Detail Information