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Mutation Information
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Mutation Site
|
N155H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
A;D |
|
Viral Reference
|
NL4.3
|
|
Relevant Drug
|
INSTIs |
|
Country
|
Uganda |
Literature Information
|
PubMed PMID
|
32853364
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Accumulation of integrase strand transfer inhibitor resistance mutations confers high-level resistance to dolutegravir in non-B subtype HIV-1 strains from patients failing raltegravir in Uganda. |
|
Author
|
Ndashimye E,Avino M,Olabode AS,Poon AFY,Gibson RM,Li Y,Meadows A,Tan C,Reyes PS,Kityo CM,Kyeyune F,Nankya I,Quiñones-Mateu ME,Arts EJ |
|
Evidence
|
INSTI DRMs were detected in 47% of patients. HIV integrase-recombinant virus carrying one primary INSTI DRM (N155H or Y143R/S) was susceptible to dolutegravir but highly resistant to raltegravir and elvitegravir (>50-fold change).
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HIV Mutation Detail Information