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HIV Mutation Detail Information

> N155H Search Result


Mutation Information
Mutation Site N155H
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Literature Information
PubMed PMID 31761656
Published Year 2020
Journal Bioorganic & medicinal chemistry letters
Title Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Author Peese KM,Naidu BN,Patel M,Li C,Langley DR,Terry B,Protack T,Gali V,Lin Z,Samanta HK,Zheng M,Jenkins S,Dicker IB,Krystal MR,Meanwell NA,Walker MA
Evidence A series of heterocyclic pyrimidinedione-based HIV-1 integrase inhibitors was prepared and screened for activity against purified integrase enzyme and/or viruses modified with the following mutations within integrase: Q148R, Q148H/G140S and N155H.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation