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Mutation Information
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Mutation Site
|
N155H |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Relevant Drug
|
raltegravir (RAL);etravirine(ETR);darunavir (DRV);ritonavir;enfuvirtide (T20);tenofovir (TDF);emtricitabine (FTC);elvitegravir (EVG) |
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Country
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France |
Literature Information
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PubMed PMID
|
20436677
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2010 |
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Journal
|
PloS one |
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Title
|
The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions. |
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Author
|
Reigadas S,Anies G,Masquelier B,Calmels C,Stuyver LJ,Parissi V,Fleury H,Andreola ML |
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Evidence
|
The emergence of the N155H mutation was replaced by a pattern including the Y143R/C/H mutations in three patients with anti-HIV treatment failure.
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HIV Mutation Detail Information