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Mutation Information
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Mutation Site
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N142T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Relevant Drug
|
INSTIs |
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Country
|
US |
Literature Information
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PubMed PMID
|
31617907
|
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Disease
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HIV infection/AIDS
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Published Year
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2020 |
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Journal
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The Journal of antimicrobial chemotherapy |
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Title
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Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance. |
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Author
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Tzou PL,Rhee SY,Descamps D,Clutter DS,Hare B,Mor O,Grude M,Parkin N,Jordan MR,Bertagnolio S,Schapiro JM,Harrigan PR,Geretti AM,Marcelin AG,Shafer RW,WHO HIVResNet Working Groups. |
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Evidence
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Thirty-two additional non-polymorphic mutations that occurred in five or more INSTI-treated persons were significantly selected by INSTI therapy (corrected P value ≤0.05), including four mutations at established INSTI-resistance positions (H51D, E92A, Q95R and N155D) and one mutation (N142T) in the highly conserved catalytic loop extending between positions 140 and 149 (Table 4).
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HIV Mutation Detail Information