Mutation Information
Mutation Site
|
N126K |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Gp41 |
Country
|
Spain |
Literature Information
PubMed PMID
|
22333046
|
Clinical information
|
Yes
|
Disease
|
HIV infection/AIDS
|
Published Year
|
2012 |
Journal
|
Retrovirology |
Title
|
The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype. |
Author
|
Cunyat F,Marfil S,García E,Svicher V,Pérez-Alvárez N,Curriu M,Perno CF,Clotet B,Blanco J,Cabrera C |
Evidence
|
Most of the recombinant plasmids constructed from sequences obtained during ENF treatment carried the V38A mutation as the only change associated with ENF resistance, although four clones derived from the 140N patient carried the N42T mutation, and three others showed the N126K mutation.
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