HBV Mutation Detail Information

> N103D Search Result


Mutation Information
Mutation Site N103D
Mutation Type Amino acid level
Gene/Protein/Region Type PreS1
Genotype/Subtype D
Viral Reference AY090460; AY090457; AY090454; AF405706; AB064310; AF160501; AF223965; AB036910; X69798; AB032431; X75657; X85254; M32138; X65259; AB014381; M12906; X04615; AB033554; AF100309; D00329; AF090842; X51970; X02763
Country Italy
Literature Information
PubMed PMID 27486882
Disease Occult HBV infection; Hepatocellular carcinoma; Liver cirrhosis
Published Year 2016
Journal Oncotarget
Title Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study.
Author Coppola N,Onorato L,Iodice V,Starace M,Minichini C,Farella N,Liorre G,Filippini P,Sagnelli E,de Stefano G
Evidence In patient n°4, apart from the AA substitution Q129H in the S region in both tissues, sequencing in HCC and non-HCC liver tissue showed differences in the AA substitutions and deletions both in the pre-S1 region (T40S and AA deletion in positions 4, 8 and 17 for HCC and S98T, N103D, T114I, T119P and the AA deletion in position 128-131 for non-HCC liver tissue) and in the pre-S2 region (no AA substitution or deletion in HCC tissue and the AA substitutions F75S and Q184H and AA deletion in position 19-22 in the non-HCC liver tissue).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation