HIV Mutation Detail Information

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Mutation Information

Mutation Site	M8A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vif
Combined Mutation	vif.M8A+vif.V7A

Literature Information

PubMed PMID	28302150
Published Year	2017
Journal	Retrovirology
Title	Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function.
Author	Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK
Evidence	Thus, in the presence of normal levels of CBFbeta, the V7A-M8A and W11A mutants either showed no defect or a modest twofold defect in rescuing virus infectivity compared to WT Vif (Fig. 3c), but in CBFbeta-depleted cells, the same mutants showed significant defects in rescuing virus infectivity (approximately threefold and 4.5-fold, respectively).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation