HBV Mutation Detail Information

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Mutation Information

Mutation Site	M552V
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Combined Mutation	p.M552V+p.L528M
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	12121939
Published Year	2002
Journal	Antimicrobial agents and chemotherapy
Title	Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus.
Author	Ono-Nita SK,Kato N,Shiratori Y,Carrilho FJ,Omata M
Evidence	The emergence of resistant hepatitis B virus (HBV) with the L528M mutation and/or the M552V and M552I mutations in the polymerase gene following long-term lamivudine treatment is becoming an important clinical problem.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation