HBV Mutation Detail Information

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Mutation Information
Mutation Site M552V
Mutation Type Amino acid level
Gene/Protein/Region Type P
Genotype/Subtype D
Relevant Drug lamivudine (LAM)
Country Japan
Literature Information
PubMed PMID 11181644
Published Year 2001
Journal The Journal of clinical investigation
Title The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance.
Author Ono SK,Kato N,Shiratori Y,Kato J,Goto T,Schinazi RF,Carrilho FJ,Omata M
Evidence After receiving lamivudine for 3 years to treatChronic hepatitis B, 67-75% of patients develop B-domain L528M, C-domain M552I, or M552V mutations in the HBV polymerase that render hepatitis B virus (HBV) drug-resistant.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation