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Mutation Information
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Mutation Site
|
M552V |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
lamivudine (LAM);famciclovir (FCV) |
Literature Information
|
PubMed PMID
|
10385663
|
|
Disease
|
HBV infection
|
|
Published Year
|
1999 |
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Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation. |
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Author
|
Tillmann HL,Trautwein C,Bock T,Böker KH,Jäckel E,Glowienka M,Oldhafer K,Bruns I,Gauthier J,Condreay LD,Raab HR,Manns MP |
|
Evidence
|
However, 7 patients developed a breakthrough within 12, 29 (n = 2), 32, 37, 54, and 145 weeks under treatment with LAM associated with the methionine-to-valine signature mutation (M552V) in the YMDD motif in all.
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HBV Mutation Detail Information