HBV Mutation Detail Information

> M552I Search Result


Mutation Information
Mutation Site M552I
Mutation Type Amino acid level
Gene/Protein/Region Type P
Combined Mutation p.M552I+p.L528M
Relevant Drug lamivudine (LAM)
Literature Information
PubMed PMID 10827158
Disease HBV infection
Published Year 2000
Journal Hepatology (Baltimore, Md.)
Title Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy.
Author Yeh CT,Chien RN,Chu CM,Liaw YF
Evidence Of the 23 patients included, 13 harbored either one or a mixture of the two common YMDD-motif mutants (methionine 552-to-isoleucine [M552I] and leucine 528-to-methionine/methionine 552-to-valine [L528M/M552V]) throughout the course, whereas in the remaining 10 patients, distinct mutants became dominant over the original mutants to cause continuing chronic hepatitis.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation