HBV Mutation Detail Information

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Mutation Information
Mutation Site M550V
Mutation Type Amino acid level
Gene/Protein/Region Type P
Genotype/Subtype C
Relevant Drug lamivudine (LAM)
Country Japan
Literature Information
PubMed PMID 10502255
Disease Chronic hepatitis B
Published Year 1999
Journal Journal of medical virology
Title Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B.
Author Ogata N,Fujii K,Takigawa S,Nomoto M,Ichida T,Asakura H
Evidence Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for methionine at residue 550 (M550I or M550V) in the catalytic site of the virus polymerase.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation