|
Mutation Information
|
Mutation Site
|
M550I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
15469692
|
|
Published Year
|
2004 |
|
Journal
|
Journal of biochemistry and molecular biology |
|
Title
|
Increased DNA polymerase fidelity of the Lamivudine resistant variants of human hepatitis B virus DNA polymerase. |
|
Author
|
Hong YB,Choi Y,Jung G |
|
Evidence
|
The FLAG-tagged wild-type (FPolE) and Met550 variants (FPolE/M550A, M550V, and M550I) of HBV DNA polymerases were expressed in insect cells, then purified.
|
|
|
HBV Mutation Detail Information