Mutation Information
Mutation Site
|
M550I |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
P |
Genotype/Subtype
|
A |
Relevant Drug
|
lamivudine (LAM);2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU) |
Literature Information
PubMed PMID
|
11502520
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2001 |
Journal
|
Antimicrobial agents and chemotherapy |
Title
|
In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil. |
Author
|
Chin R,Shaw T,Torresi J,Sozzi V,Trautwein C,Bock T,Manns M,Isom H,Furman P,Locarnini S |
Evidence
|
We found that the M550I and M550V plus L526M substitutions, which confer lamivudine resistance, did not confer cross-resistance to adefovir or DAPD, but conferred cross-resistance to L-FMAU.
|
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