HBV Mutation Detail Information

> M550I Search Result


Mutation Information
Mutation Site M550I
Mutation Type Amino acid level
Gene/Protein/Region Type P
Genotype/Subtype A
Relevant Drug lamivudine (LAM);2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU)
Literature Information
PubMed PMID 11502520
Disease Chronic hepatitis B
Published Year 2001
Journal Antimicrobial agents and chemotherapy
Title In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Author Chin R,Shaw T,Torresi J,Sozzi V,Trautwein C,Bock T,Manns M,Isom H,Furman P,Locarnini S
Evidence We found that the M550I and M550V plus L526M substitutions, which confer lamivudine resistance, did not confer cross-resistance to adefovir or DAPD, but conferred cross-resistance to L-FMAU.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation