HBV Mutation Detail Information

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Mutation Information

Mutation Site	M550I
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Combined Mutation	p.L426I+p.M550I
Genotype/Subtype	C
Relevant Drug	lamivudine (LAM)
Country	Japan

Literature Information

PubMed PMID	10502255
Disease	Chronic hepatitis B
Published Year	1999
Journal	Journal of medical virology
Title	Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B.
Author	Ogata N,Fujii K,Takigawa S,Nomoto M,Ichida T,Asakura H
Evidence	Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for methionine at residue 550 (M550I or M550V) in the catalytic site of the virus polymerase.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation