HBV Mutation Detail Information

> M539V Search Result

Mutation Information

Mutation Site	M539V
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	9862871
Disease	Chronic hepatitis B
Published Year	1999
Journal	Hepatology (Baltimore, Md.)
Title	Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance.
Author	Pichoud C,Seignères B,Wang Z,Trépo C,Zoulim F
Evidence	Resistant viruses, with mutations in thecatalytic site (domain C) ofthe viral polymerase (M539V andM539I), similar to that observed in HIV resistant strains to 3TC, may be selected after 12 months of lamivudine treat-ment in approximately 15% of chronic HBV patients and upto 25% of the patients in the liver transplant setting

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation