|
Mutation Information
|
Mutation Site
|
M539V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Combined Mutation
|
p.M539V+s.I195M |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
9687422
|
|
Published Year
|
1998 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2'-deoxy-3'-thiacytidine and a reduced ability to synthesize viral DNA. |
|
Author
|
Ladner SK,Miller TJ,King RW |
|
Evidence
|
The M539V Polymerase Variant of Human Hepatitis B Virus Demonstrates Resistance to 2′-Deoxy-3′-Thiacytidine and a Reduced Ability to Synthesize Viral DNA
|
|
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HBV Mutation Detail Information