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HIV Mutation Detail Information

> M475A Search Result


Mutation Information
Mutation Site M475A
Mutation Type Amino acid level
Gene/Protein/Region Type Gp120
Literature Information
PubMed PMID 23011758
Published Year 2013
Journal Proteins
Title HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism.
Author Tuzer F,Madani N,Kamanna K,Zentner I,LaLonde J,Holmes A,Upton E,Rajagopal S,McFadden K,Contarino M,Sodroski J,Chaiken I
Evidence D474A and K421A since these mutants were shown to be important for peptide triazole function in later studies (not shown) and showed differences in the ELISA screen, E370A as this mutant was tested for the first time and showed a great difference with WT in the KR21 ELISA screen;T257A and M475A as these mutations had shown effects on antiviral potency (not shown) of the peptide triazole HNG-156 and also affected CD4 inhibition by KR21 in the ELISA screen;M95A was a mutant selected as a control for no effect (less than 2-fold) on PT activity.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation