|
Mutation Information
|
Mutation Site
|
M46L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Viral Reference
|
K03455.1
|
|
Country
|
North Carolina |
Literature Information
|
PubMed PMID
|
32663847
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Near Real-Time Identification of Recent Human Immunodeficiency Virus Transmissions, Transmitted Drug Resistance Mutations, and Transmission Networks by Multiplexed Primer ID-Next-Generation Sequencing in North Carolina. |
|
Author
|
Zhou S,Sizemore S,Moeser M,Zimmerman S,Samoff E,Mobley V,Frost S,Cressman A,Clark M,Skelly T,Kelkar H,Veluvolu U,Jones C,Eron J,Cohen M,Nelson JAE,Swanstrom R,Dennis AM |
|
Evidence
|
In contrast, the prevalence of PR region mutations M46L/I, D30N, V82A, and RT region mutations M41L, D67N, G190E, T215F/I/C/ D/V/E increased greatly (up to 10-fold), with an increase in detection sensitivity from 30% to 0.3%.
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HIV Mutation Detail Information