|
Mutation Information
|
Mutation Site
|
M46L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
Literature Information
|
PubMed PMID
|
32605062
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
Multi-Laboratory Comparison of Next-Generation to Sanger-Based Sequencing for HIV-1 Drug Resistance Genotyping. |
|
Author
|
Parkin NT,Avila-Rios S,Bibby DF,Brumme CJ,Eshleman SH,Harrigan PR,Howison M,Hunt G,Ji H,Kantor R,Ledwaba J,Lee ER,Matías-Florentino M,Mbisa JL,Noguera-Julian M,Paredes R,Rivera-Amill V,Swanstrom R,Zaccaro DJ,Zhang Y,Zhou S,Jennings C |
|
Evidence
|
Specimen Viral Load a Subtype b PR DRMs c RT DRMs c % Mixed Bases in SS Consensus d Number of Amplification Failures 24.1 7815 B None T215C 2.3% 0 24.2 18,023 F K20R, M36I None 0.0% 0 24.3 26,372 C M36I M41L, V75T, V90I, V106M, V179D 0.0% 0 24.4 29,139 C M36I M41L, K103N, M184V, T215Y 0.1% 1 24.5 6424 B L10I, L33F, M46L, I54V, A71I/T, V82A, L90M M41L, E44D, A62V, D67N, L74V, L100I, K103N, H208Y, L210W, T215Y H221Y 0.8% 1 26.1 16,685 C M36I, T74S D67N, K70R, V90I, M184V 0.9% 0 26.2 e 4513 B L10I, L33F, M46L, I54V, A71I/T, V82A, L90M M41L, E44D, A62V, D67N, L74V, L100I, K103N, H208Y, L210W, T215Y, H221Y 1.1% 1 26.3 18,213 C K20R, M36I A62V, K65R, D67N, V75A/I/T, K101Q, K103N, V106M, E138A, M184V 2.1% 1 26.4 6506 D M36I None 1.1% 2 26.5 3656 B none V90I, K103N 3.8% 0 Characteristics of Virology Quality Assurance (VQA) specimens used in this study. a RNA copies/mL.
|
|
|
HIV Mutation Detail Information