|
Mutation Information
|
Mutation Site
|
M46L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
atazanavir (ATV);fosamprenavir (FPV);indinavir (IDV);lopinavir (LPV);saquinavir (SQV);tipranavir (TPV);etravirine (ETR);nevirapine (NVP);rilpivirine (RPV);nelfinavir (NFV);doravirine (DOR) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
32371875
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Scientific reports |
|
Title
|
HIV-1 molecular epidemiology and drug resistance-associated mutations among treatment-naïve blood donors in China. |
|
Author
|
Zhao J,Lv X,Chang L,Ji H,Harris BJ,Zhang L,Jiang X,Guo F,Hackett J Jr,Yin P,Cloherty GA,Rodgers MA,Wang L |
|
Evidence
|
The PI major DRMs included M46L, M46I and N88S. M46I/L caused PLLR to many INSTIs among HIV-1 positive individuals, while N88S could result in HLR to Atazanavir (ATV) and NFV, LLR to Indinavir (IDV) and Saquinavir (SQV).
|
|
|
HIV Mutation Detail Information