HIV Mutation Detail Information

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Mutation Information
Mutation Site M46L
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Relevant Drug atazanavir (ATV);fosamprenavir (FPV);indinavir (IDV);lopinavir (LPV);saquinavir (SQV);tipranavir (TPV);etravirine (ETR);nevirapine (NVP);rilpivirine (RPV);nelfinavir (NFV);doravirine (DOR)
Country USA
Literature Information
PubMed PMID 32371875
Disease HIV infection/AIDS
Published Year 2020
Journal Scientific reports
Title HIV-1 molecular epidemiology and drug resistance-associated mutations among treatment-naïve blood donors in China.
Author Zhao J,Lv X,Chang L,Ji H,Harris BJ,Zhang L,Jiang X,Guo F,Hackett J Jr,Yin P,Cloherty GA,Rodgers MA,Wang L
Evidence The PI major DRMs included M46L, M46I and N88S. M46I/L caused PLLR to many INSTIs among HIV-1 positive individuals, while N88S could result in HLR to Atazanavir (ATV) and NFV, LLR to Indinavir (IDV) and Saquinavir (SQV).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation