HIV Mutation Detail Information

> M46L Search Result


Mutation Information
Mutation Site M46L
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Relevant Drug bictegravir (BIC);emtricitabine (FTC);tenofovir alafenamide
Country Australia;Europe;North America
Literature Information
PubMed PMID 31430369
Disease HIV infection/AIDS
Published Year 2019
Journal The Journal of antimicrobial chemotherapy
Title Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I.
Author Andreatta K,Willkom M,Martin R,Chang S,Wei L,Liu H,Liu YP,Graham H,Quirk E,Martin H,White KL
Evidence PI-R substitutions were observed in 10% (55/543), with M46I/L (4.1%, 22/543) and L90M (2.4%, 13/543) most frequently detected.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation