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Mutation Information
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Mutation Site
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M46L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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atazanavir (ATV);fosamprenavir (FPV);indinavir (IDV);lopinavir (LPV);nelfinavir (NFV);saquinavir (SQV);tipranavir (TPV) |
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Country
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India |
Literature Information
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PubMed PMID
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30315192
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Disease
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HIV infection/AIDS
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Published Year
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2018 |
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Journal
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Scientific reports |
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Title
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Antiretroviral resistance, genotypic characterization and origin of Human Immunodeficiency Virus among the infected wives of Intravenous drug users in Manipur. |
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Author
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Sharma AL,Singh TR,Singh LS |
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Evidence
|
The common DRMs found among the ART treatment experienced individuals were targeted at (i) NRTI positions: M184V (10%, 3/30), M184I (6.7%, 2/30) and M41L, D67N, T69D, K70G/R, Y115F, T215N and K219R/Q (3.3% each, 1/30) (ii) NNRTI positions: A98G, K103N, V179D/E, Y181C, G190A/R (6.7% each, 2/30), K101E, V106A/M, V108I, Y181F, H221Y and M230I (3.3% each, 1/30) and (iii) protease inhibitors positions: major mutation M46L (3.3%, 1/30) and other mutations L24I, G48K and G73S (3.3% each, 1/30).
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HIV Mutation Detail Information