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Mutation Information
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Mutation Site
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M46L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
|
PIs |
Literature Information
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PubMed PMID
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27039930
|
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Published Year
|
2016 |
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Journal
|
Biochemistry |
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Title
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Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme. |
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Author
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Park JH,Sayer JM,Aniana A,Yu X,Weber IT,Harrison RW,Louis JM |
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Evidence
|
Three of five mutations in PRS17 correlating with major drug resistance, M46L, G48V and V82S, and five of eleven natural variations, differ from two clinically derived extreme mutants, PR20 and PR22 bearing 19 and 22 mutations, respectively.
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HIV Mutation Detail Information