|
Mutation Information
|
Mutation Site
|
M46L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Genotype/Subtype
|
C |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
22293461
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2012 |
|
Journal
|
Antiviral therapy |
|
Title
|
Low rates of nucleoside reverse transcriptase inhibitor resistance in a well-monitored cohort in South Africa on antiretroviral therapy. |
|
Author
|
Wallis CL,Papathanasopolous MA,Fox M,Conradie F,Ive P,Orrell C,Zeinecker J,Sanne I,Wood R,McIntyre J,Stevens W,CIPRA-SA project 1 study team. |
|
Evidence
|
Of the five with resistance at enrollment, no NRTI resistance was observed, two had resistance to NNRTIs (K103N n=1; V106M, K103N n=1), two had protease resistance (M46I n=1, M46L n=1) and one had both protease and NNRTI resistance (M46V, K101E, G190A).
|
|
|
HIV Mutation Detail Information