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Mutation Information
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Mutation Site
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M46I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Genotype/Subtype
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CRF07_BC; CRF08_BC; CRF01_AE; B; CRF55_01B; CRF59_01B;CRF68_01B |
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Relevant Drug
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PIs |
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Country
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China |
Literature Information
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PubMed PMID
|
33347449
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Disease
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HIV infection/AIDS
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Published Year
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2020 |
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Journal
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PloS one |
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Title
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The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014-2017. |
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Author
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Liang S,Liu Z,Wang S,Liu J,Shi L,Mao W,Liu C,Wan J,Zhu L,Huang M,Liu Y,Wang J,Ness P,Shan H,Zeng P,He M |
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Evidence
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48 DRMs were identified from 43 samples, indicating a drug resistance prevalence of 12.1% (43/356), which include seven protease inhibitors (PIs) accessory DRMs (Q58E, L23I and I84M), two PIs major DRMs (M46I, M46L), seven nucleoside RT inhibitors DRMs (D67N, K70Q, K219R and M184L), and 32 non-nucleoside RT inhibitors DRMs (K103N, V179E, K238N, V179D, E138G, G190E, A98G, Y188D and E138A).
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HIV Mutation Detail Information