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Mutation Information
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Mutation Site
|
M46I |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
|
Genotype/Subtype
|
B |
Literature Information
|
PubMed PMID
|
31591964
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
eLife |
|
Title
|
Epistasis and entrenchment of drug resistance in HIV-1 subtype B. |
|
Author
|
Biswas A,Haldane A,Arnold E,Levy RM |
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Evidence
|
The comparison of the effects of point mutations is shown in terms of Potts ΔE scores (which forms the basis of our study) using two different Potts models, parameterized on drug-naive vs drug-experienced sequences for PR drug-resistance mutations M46I (A), I54V (B), V82A (C), and L90M (D), all of which appear with at least a frequency of 0.25% in both datasets.
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HIV Mutation Detail Information