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Mutation Information
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Mutation Site
|
M46I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
PIs |
|
Country
|
Haiti |
Literature Information
|
PubMed PMID
|
30640198
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
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Journal
|
The Pediatric infectious disease journal |
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Title
|
High Levels of HIV-1 Drug Resistance in Children Who Acquired HIV Infection Through Mother to Child Transmission in the Era of Option B+, Haiti, 2013 to 2014. |
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Author
|
Louis FJ,Segaren N,Desinor O,Beard RS,Jean-Louis R,Chang J,Boisson S,Hulland EN,Wagar N,DeVos J,François K,Buteau J,Boncy J,Marston BJ,Domerçant JW,Yang C,Charles M |
|
Evidence
|
One child had a major M46I PI mutation, which causes low level of resistance to all PIs except darunavir and tipranavir, and another had the I50L major PI mutation, which causes high level resistance to atazanavir (Table 1).
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HIV Mutation Detail Information