|
Mutation Information
|
Mutation Site
|
M46I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
PIs;saquinavir (SQV) |
Literature Information
|
PubMed PMID
|
30401010
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
|
Journal
|
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
|
Title
|
Characterisation of HIV-1 transmission clusters and drug-resistant mutations in Denmark, 2004 to 2016. |
|
Author
|
Petersen A,Cowan SA,Nielsen J,Fischer TK,Fonager J |
|
Evidence
|
For PI, one subtype had mutations resulting in high-level resistance to saquinavir/r (M46I and L90M) and seven subtypes had mutations leading to high-level resistance to nelfinavir (one M46I and L90M and six L90M).
|
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HIV Mutation Detail Information