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Mutation Information
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Mutation Site
|
M46I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
PIs |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
29870534
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
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Journal
|
PloS one |
|
Title
|
Epidemiological surveillance of HIV-1 transmitted drug resistance among newly diagnosed individuals in Shijiazhuang, northern China, 2014-2015. |
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Author
|
Wang X,Liu X,Li F,Zhou H,Li J,Wang Y,Liu L,Liu S,Feng Y,Wang N |
|
Evidence
|
The M46I/L, PI-associated mutation, was the most frequent mutation observed in 2.2% (12/542) of individuals, while the most commonly observed NNRTIs resistance associated mutations were K101E (0.7%) and Y181C (0.7%), followed by V106M (0.60%), and the most prevalent resistance mutation of NRTIs was L210W(0.70%).
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HIV Mutation Detail Information