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Mutation Information
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Mutation Site
|
M46I |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
PIs |
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Country
|
Brazil |
Literature Information
|
PubMed PMID
|
29844604
|
|
Disease
|
HIV-HBV coinfection;
HIV-HCV coinfection
|
|
Published Year
|
2018 |
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Journal
|
Scientific reports |
|
Title
|
HIV Reverse Transcriptase and Protease Genes Variability Can Be a Biomarker Associated with HIV and Hepatitis B or C Coinfection. |
|
Author
|
Cantão NM,Fogaça de Almeida L,Rodrigo Wolf I,Oliveira Almeida R,Alves de Almeida Cruz A,Nunes C,Barbosa AN,Valente GT,de Moura Campos Pardini MI,Grotto RMT |
|
Evidence
|
K103N was the NNRTI mutation most frequently found in co-infected patients (14.7%). The major mutations to PI were I54V (2.9%), V82A (11.7%), M46I (8.8%) and L90M (40.4%). On the other hand, the minor mutations to PI found were S37N (32.3%), I15V (26.5%) and M36I (23.5%).
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HIV Mutation Detail Information