|
Mutation Information
|
Mutation Site
|
M46I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
PIs |
Literature Information
|
PubMed PMID
|
17500586
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2007 |
|
Journal
|
PLoS computational biology |
|
Title
|
HIV-1 subtype B protease and reverse transcriptase amino acid covariation. |
|
Author
|
Rhee SY,Liu TF,Holmes SP,Shafer RW |
|
Evidence
|
Different patterns of covariation were frequently observed for different mutations at the same position including the RT mutations T69D versus T69N, L74V versus L74I, V75I versus V75M, T215F versus T215Y, and K219Q/E versus K219N/R, and the protease mutations M46I versus M46L, I54V versus I54M/L, and N88D versus N88S.
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HIV Mutation Detail Information