|
Mutation Information
|
Mutation Site
|
M434I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gp120 |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
fostemsavir |
Literature Information
|
PubMed PMID
|
32160290
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Identification of gp120 polymorphisms in HIV-1 B subtype potentially associated with resistance to fostemsavir. |
|
Author
|
Bouba Y,Berno G,Fabeni L,Carioti L,Salpini R,Aquaro S,Svicher V,Perno CF,Ceccherini-Silberstein F,Santoro MM |
|
Evidence
|
RESULTS: The prevalence of fostemsavir resistance mutations was as follows: L116Q (0.05%), S375H/M/T (0.55%/1.35%/17.73%, the latter being far less relevant in determining resistance), M426L (7.56%), M434I (4.21%) and M475I (1.65%).
|
|
|
HIV Mutation Detail Information