|
Mutation Information
|
Mutation Site
|
M41L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.S215Y+rt.K70R+rt.D67N+rt.M41L |
Literature Information
|
PubMed PMID
|
32129987
|
|
Published Year
|
2020 |
|
Journal
|
ACS infectious diseases |
|
Title
|
Defective Strand-Displacement DNA Synthesis Due to Accumulation of Thymidine Analogue Resistance Mutations in HIV-2 Reverse Transcriptase. |
|
Author
|
Martín-Alonso S,Álvarez M,Nevot M,Martínez MÁ,Menéndez-Arias L |
|
Evidence
|
In contrast, mutants D67N/K70R/S215Y and M41L/D67N/K70R/S215Y were the most defective RTs in reactions carried out with nicked and gapped substrates.
|
|
|
HIV Mutation Detail Information